The two most commonly used opioid antagonists are Naloxone and Naltrexone. These are competitive antagonists. They are used to treat drug and alcohol dependence. The common drug class indicates that both medications are applied for the receptor’s binding site. But there are differences in the use of Naloxone and Naltrexone (Revia). Let’s compare the differences of these two similar but various pills.
Naltrexone stands for the drug, the effect of drugs known antagonist opioids. It has the greatest affinity for the nervous receptors. Naltrexone eliminates the effects of opioids (including endogenous). When to compare Naltrexone vs Naloxone the first one acts more strongly and for a long time. The onset of action of Naltrexone is after 1-2 hours.
Among contradictions of Naltrexone is hypersensitivity (including Naloxone), a state of abstinence on the background of opioid dependence, acute hepatitis, liver failure, positive test with Naloxone, pregnancy, lactation, age under 18 years. If you have a liver or kidney condition please consider using less doses of Naltrexone. Be cautious when using Naltrexone during pregnancy and lactation has not been established.
At the same time the long-term administration of Naltrexone prevents the development of physical dependence to morphine, heroin and others. At a dose of 50 mg Naltrexone blocks the pharmacological effects of 25 mg / in the introduction of heroin for 24 hours, a double dose (100 mg) acts within 48 hours, and 150 mg will affect during for 3 days. Long-term appointment does not cause tolerance and dependence. The combination with opioids in high doses leads to increased release of histamine with a characteristic clinical picture (facial flushing, itching, rash). In patients with opioid dependence, Naltrexone causes attack symptoms.
Naloxone is available in the form of capsules and tablets under the trademarks in the form of sterile capsules for subcutaneous implantation under the trademarks. Treatment with Naloxone is possible only after removing the alcohol dependence’s syndrome (brittle), otherwise, Naloxone dramatically enhances abstinence.
To prevent premature application of Naloxone with the experts test with Naltrexone then the duration of which lasts 30-40 minutes. If after administration of Naloxone does not change the condition of the patient –then apply Naltrexone.
The validity of Naloxone capsule for oral intake that lasts up to 24 hours, taking two capsules prolongs the action up to 48 hours, and three capsules will act during 72 hours, a further increase in the dose does not increase the duration of action.
To cut the long story short, when comparing Naltrexone vs Naloxone it is obvious that Naltrexone is stronger for alcohol dependence but Naloxone acts faster and remains longer.