GENERIC CIALIS (Tadalafil 80/60/40/20/10/5/2.5 mg)

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Brand Name
GENERIC CIALIS
Product Name
Tadalafil
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WHAT IS CIALIS?

Cialis is a drug that has tadalafil as an active ingredient. Although it is mainly used for treating impotence in men, it may also be prescribed for managing various symptoms of BPH. Tadalafil belongs to PDE5 inhibitors that help smooth certain muscles, which increases the blood flow to the penis. The medication is sold in tablets containing 2.5mg, 5mg, 10mg, or 20mg and taken orally according to doctor’s recommendations. Cialis remain active for the next 36 hours after you use it, which is one of the matters distinguishing it from many other ED drugs. The medicine will not cause the needed effect without sexual stimulation. It is not suitable for women or children and should be stored properly. There are no generic versions of Cialis available on the market.

WHAT DOSAGES MAY BE USED?

The usual starting dosage of this medication is 10 mg to take before sexual intercourse, but a man may be prescribed with another dosage ranging from 5mg to 20 mg based on different factors, including the efficacy and safety of this drug in a particular patient. The medicine should be taken maximum one time per day, even if you use it in the smallest dosage.

It is also possible to use this drug to improve sexual ability on a daily basis, and in this case, the medication is usually prescribed in a daily dosage of 2.5 mg. The daily dosage may be changed under the supervision of a healthcare provider, buy it should be no more than 5 mg.

To treat BPH, the medication is usually prescribed in a daily dosage of 5 mg. The length of the treatment is determined by a healthcare provider depending on the drug effects and may be from 4 to 26 weeks. The medicine can be taken regardless of food intake.

HOW TO USE THIS MEDICATION SAFELY?

Cialis is prescribed for a patient based on his complaints and the overall health conditions. Special attention should be paid to men who have the following medical problems:

  • Heart problems;
  • Severe vision loss;
  • Pulmonary hypertension;
  • A long-lasting erection;
  • Stroke;
  • Retinitis pigmentosa;
  • Liver/kidney problems;
  • Low/high blood pressure;
  • Bleeding problems;
  • Stomach ulcers;
  • Peyronie’s disease;
  • Blood cell disorders.

This drug’s components may cause an allergic reaction, which makes it impossible to use it further.

When taking Cialis, avoid using too much alcohol because this may lead to the following side effects:

  • Lowered blood pressure;
  • A headache;
  • Dizziness;
  • Increased heart rate.

It is essential to avoid consuming grapefruit/grapefruit juice while using this medication because it may interact with its main ingredient leading to unwanted side effects.

WHAT ARE COMMON/UNCOMMON SIDE EFFECTS?

Common side effects that usually disappear after several hours:

  • Back pain;
  • A headache;
  • Flushing;
  • Indigestion;
  • Muscle aches;
  • Stuffy/runny nose.

Muscle aches and back pain may last for two days.

Severe side effects (uncommonly met):

  • A long-lasting erection (more than four hours);
  • Severe vision problems, including vision loss;
  • Severe hearing problems, including hearing loss

WHAT MEDICATIONS SHOULD NOT BE COMBINED WITH CIALIS?

The combination of Cialis with some other medicines may cause drug interactions ranging from mild to severe. Do not use this drug with the following medications:

  • Nitrates;
  • Guanylate cyclase stimulators;
  • Blood pressure drugs
  • HIV medications;
  • Some oral antifungal medicines;
  • Alpha-blockers;
  • Some antibiotics, including the following generic names: telithromycin, erythromycin, clarithromycin, and others;
  • Other ED medications.

Comprehensive Information on Cialis (Tadalafil)

Cialis is the brand name of the FDA approved drug tadalafil. As Cialis, it is used in treating erectile dysfunction (ED) in men; as Adcirca, tadalafil is used in treating pulmonary arterial hypertension. Cialis belongs to a class of drugs called PDE5 inhibitors. They stop the degenerative attack by cGMP-specific phosphodiesterase type 5 (PDE5) on proteins lining the smooth muscles in the penis.

Generic drugs are exact copies of branded drugs approved by the FDA which are manufactured by companies other than the one that had the drug patented and sold under its name. Such drugs are sold cheaper than their branded counterparts since they aren’t completely developed from scratch and the cost of bringing them to the market is lower.

Read on to find out more about this drug and its uses, discovery, manufacturing process, and side effects

COMMON USES

On sexual arousal, the penis’s nervous tissues release Nitric 0xide (NO) and due to this, an enzyme producing a messenger called cyclic guanosine monophosphate (cGMP) is stimulated. cGMP has a relaxing effect on the muscles and blood vessels of the penis, allowing the blood to flow into the penis easily. In men with erectile dysfunction, PDE5 is in higher concentrations and performs a degenerative action on cGMP messenger, reducing blood flow to the penis. Cialis, as well as other PDE5 inhibitors, come in the way of this degenerative action.

Cialis has another common use as well: treating the symptoms of benign prostatic hyperplasia (BPH). It is a non-cancerous increase in the size of the prostate. Large nodules form in the transition zone of the urethra putting pressure on it. This leads to obstruction in urine flowing from the bladder, causing urination difficulty and an added urge to pass more urine at night. It is very common among men older than 50, nearly 45% develop BPH and 75% have it by the time they are 80. In 2008, the FDA approved the use of Cialis for BPH which was reported to be occurring along with ED in some men. Clinical trials have shown significant reduction in BPH symptoms as a result of Cialis treatment.

DEVELOPMENT

Cialis was discovered during a joint venture between GlaxoSmithKline (then Glaxo Wellcome) and ICOSin 1991. Further study was done by ICOS on a compound named IC351, a PDE5 inhibitor. In 1994, Pfizer accidently discovered that sildenafil, another PDE5 inhibitor, caused penile erection in clinical subjects undergoing tests for heart ailments. Seeing this, ICOS scientists tried using IC351 to treat ED. In 1996, ICOS’s contract with Glaxo lapsed and in 2000, Lilly ICOS LLC (joint venture between ICOS and Eli Lilly & Company) filed for FDA approval for IC351 under the name tadalafil. 3 years later, they were granted approval and began selling it under the brand name Cialis. The advantage Cialis has had over Viagra and Levitra is its highly increased half-life. Cialis’s half-life is roughly 17.5 hours compared to Viagra and Levitra’s 4-5 hours.

SIDE EFFECTS AND PRECAUTIONS

Side effects experienced while taking Cialis include headaches, back pain, muscle pain, flushing, runny nose, stomach ache, acid reflux, and burping. The side effects are mainly due to the vasodilation caused by Cialis. Most of the unwanted reactions usually go away in a few hours whereas muscular pain might reduce after 12 to 24 hours. In case the pain persists, patients should immediately discontinue taking Cialis and contact their doctor promptly.

Other rare cases of partial hearing and vision impairment were reported. Due to this, the FDA has directed the manufacturer to issue statutory warnings on the packaging as a precautionary measure.

A single, isolated case of a man having consumed Cialis with a prolonged erection (priapism) was reported in 2005. The patient did not have any other contributing signs of priapism and the erection was relieved after caverno-spongiosal shunting. In case of an erection lasting longer than 4 hours, medical help should be sought immediately to prevent permanent damage to penile tissue.

Since Cialis has a transient effect on blood pressure, it is imperative that we know about dangerous interactions the drug can have with other medications. Organic nitrates and nitrites should not be consumed within 48 hours of consuming Cialis as this could lead to life-threatening hypotension (extremely low blood pressure). If patients with angina are unable to take organic nitrates since they have consumed Cialis and experience chest pain, doctors should be contacted at once. In the event of an emergency, medical personnel must be made aware of the consumption of Cialis as it could prove vital to saving the patient’s life.

Doctors should be informed of other medications such as antibiotics, hypertension medicines, HIV meds, and other ED tablets before starting to take Cialis. Other medical conditions (especially heart ailments) and allergies must also be discussed with the doctor.

Generic Cialis from India by Dadha Pharma

Erectile dysfunction (ED) is a medical condition that all men are afraid of. It basically makes a man unable to engage in sexual activities because it prevents him from achieving an erection, or even if he does achieve it, it does not last long enough to complete sexual intercourse.

Fortunately, modern medicine has succeeded in deciphering the causes of ED and has also come up with more than a few medical products that can combat the condition and block its symptoms, at least temporarily for the time being.

Viagra is, undoubtedly, the most widespread of all ED drugs simply because it was the first one that was developed, thus receiving huge media coverage. However, there are also others, that may not be as well known but are definitely equally effective. One of them is Tadalista, a generic Cialis product that is famous for its duration since, according to the manufacturers, it can last for 36 hours after consumption. Before analyzing the drug itself, it is important to mention a few things about the manufacturer of this particular version of generic Cialis.

WHAT IS DADHA PHARMA LTD?

Dadha Pharma Limited is a pharmaceutical corporation that currently has more than 80 years of operation. It was founded in 1935 by the forefathers of the current Senior Director, Mohanchad Dadha. Aside from Tadalista, the corporation produces a variety of medicines including other ED drugs such as:

Filagra – Its active ingredient is sildenafil citrate and it comes in dosages of 25, 50 and 100 mg. So the drug is an utter equivalent of famous Viagra.

Filitra – It contains vardenafil – another PDE5 inhibitor – as its active ingredient. This drug comes in dosages of 20 mg.

Super Filagra – Containing two different active ingredients, dapoxetine and sildenafil citrate, this drug can also effectively treat premature ejaculation (PE) in addition to ED.

The biggest proof of not only the success but also the future potential of Dadha Pharma Ltd is the interest shown by the multinational pharmaceutical giant Sun Pharmaceutical Industries Limited. In 1997, it acquired Dadha Pharma, expanding the collection of top notch companies it possesses.

TADALISTA AS GENERIC CIALIS

The active ingredient in Tadalista is tadalafil, a chemical substance that can block the symptoms of ED. Currently, there is only one approved tadalafil-based drug for ED – Cialis; so all the others, even branded ones, are commonly referred to as generic Cialis.

Under normal circumstances, an erection is achieved in the following way:

After a man is stimulated sexually, his body produces certain quantities of nitric oxide which then forms bonds with guanylate cyclase receptors. This bonding increases the concentration levels of cyclic guanosine monophosphate (cGMP) leading to an elevated blood flow in the area of the penis. After these steps are completed, the man gets an erection and is ready to engage in sexual intercourse without any problems.

However, when suffering from ED, the cGMP levels cannot increase because of the existence of cGMP-specific phosphodiesterase type 5, known as PDE5. This substance prevents cGMP from accumulating, thus making an erection impossible to happen. So, all that is required is a way to block the action of PDE5, and this is exactly what Tadalista does. Through various chemical reactions, it stops the action of PDE5 (that’s why the name PDE5 inhibitor is given to its active ingredient) making the user able to achieve an erection and have sex.

Unfortunately, there are certain groups of men that are not recommended to use not only Tadalista but every ED drug in general. Suffering from one or more of the following conditions requires professional medical advice before using any PDE5 inhibitor as an ED treatment:

  • High or low blood pressure
  • Any eye condition (especially ones caused by irregular blood flow)
  • Kidney or liver issues
  • Recent stroke
  • Blood clotting problems
  • Heart disease including an irregular heartbeat.

There are also some documented side effects associated with tadalafil that may vary from one man to another. Knowing about them should not be considered as a reason to stay away from the drug, but instead, as an opportunity to be prepared for a possible adverse effect that might manifest after taking the drug. The best way to be sure that the drug is absolutely safe for you is to consult your doctor, who will let you know what the most probable side effects will be in your particular case according to your medical history.

Cialis Information

WHAT DOES 5MG OF CIALIS DO?

Main ingredient of Cialis’s is tadalafil, which is prescribed for the erectile dysfunction treatment. Sometimes it goesunder the name Adcirca and in this case is used for curing of pulmonary arterial hypertension.

IS CIALIS TAKEN EVERY DAY?

To maintain stable effect, it’s better to take Cialis on daily basis, in the same hours and in low dosage (like 5 mg). Effect from single pill goes on for about 36 hours. It’s one the most widely used treatments for erectile dysfunction (ED) in the USA.

HOW LONG DOES IT TAKE FOR CIALIS TO WORK?

Usually it takes about 20 minutes for Cialis to work, but it would be more reliable to use it 30 minutes before the sexual intercourse just to make sure. For Viagra and Levitra users it’s longer – about 60 minutes before the sexual activity. The effect of Cialis lasts from 24 to 36 hours.

WHAT IS CIALIS 5 MG USED FOR?

It’s used as a treatment of erectile dysfunctions (ED) and also for cases of benign prostatic hyperplasia (BPH). 5 mg dose is safe to take daily, better in the same hours, no matter of sexual intercourse timing.

IS CIALIS DANGEROUS TO TAKE?

Because of the small dose of tadalafil in Cialis pills, it’s safe to take it every day. Nevertheless, its effect can vary, depending on what substances you take with it. Sometimes they can interact (e.g. in case of alcohol drinking).

HOW TO GET CIALIS

Cialis (tadalafil) is one of the most popular pills for treating erectile dysfunction, and if its global sales are anything to go by, it comes in second place right after the super popular drug Viagra. However, first-time users might have some trouble obtaining the drug because not all of them know where and how to get original Cialis.

Just as is true of many other branded drugs, there are numerous Cialis counterfeits out there. Thus, you should be careful when buying. It is imperative for all men to understand that there are only two safe ways of getting the drug, namely either online or from a physical pharmacy.

Most individuals prefer to buy Cialis online because this way they are able to keep the transaction private and confidential. But, it is important to note that you may still need to have a prescription when buying from official, credible online pharmacies. Also, make sure that you purchase the drug from a reputable online pharmacy so that you can get original pills and not generic ones.

Physical pharmacy

Once your doctor ascertains that it is safe for you to take Cialis, he will give you a prescription, which you can subsequently use to buy the ED pills from an accredited pharmacy. The best thing about getting a prescription from your doctor is that he will run some tests or go through your medical history so that he can recommend the right dosage for you.

What to look out for

To make sure that you are buying genuine Cialis, you should keep in mind the following important things:

– The price should be realistic (no less than $4 for one pill). Avoid offerings that are too cheap, as they are most likely “fake”.

– Any offer that says things like “Cialis Strips” or “Chewable Cialis” should be a red flag.

– Reputable online or physical pharmacies in most cases require a prescription.

– The Cialis tablets are always almond shaped with distinct markings consisting of the letter C and the dosage, which can be 20, 10, 5 or 2.5 mg.

HOW DOES CIALIS WORK?

Before delving into how long it takes before you can expect Cialis to start improving your sexual performance, it is worth clarifying some aspects of how the drug works. Cialis is not a cure for low libido, nor will it create an erection if there is no natural trigger. So for the drug to take effect, the user must receive a certain amount of sexual stimulation. When it comes to arousal, it remains largely contingent on one’s subjective perception and response to sexual stimulation. When the factors that naturally lead to arousal work in the right direction, Cialis will simply help improve suboptimal erectile function. More specifically, what this ED drug does is facilitate an erection by dilating blood vessels and increasing blood flow to the penis. In the absence of sexual stimulation, the drug’s effects will not be noticed. With this in mind, it becomes easier to manage when to take the drug.

How soon is the onset?

On average, Cialis takes about 30 to 45 minutes to kick in. It may take only 15 minutes or up to two hours depending on the individual’s age, physiology, and psychological susceptibility. Its effects generally become more pronounced after a few hours have gone by, and will last for quite a while. Also, keep in mind that taking the pill after a hearty meal, especially a fatty one, can delay the onset of the drug.

How long does it last?

One of Cialis’ greatest advantages relative to other ED drugs is that its invigorating effect lasts much longer. It can stay in the system for up to two days. So Cialis is often preferred to other medications that work on the basis of a similar principle because the user can take advantage of the drug’s effect at any time during a period of almost two days after consumption, which gives users greater freedom and allows for more spontaneity. On average, Cialis lasts up to 36 hours, although the specific duration may vary from one individual to another.

INTERACTION: CIALIS AND ALCOHOL

Cialis is an ED drug that acts as a vasodilator. It increases blood circulation and volume in the genital region by blocking the POE-5 enzyme, which is responsible for preventing erection or making it difficult to maintain. As a matter of fact, alcohol exhibits a similar vasodilating effect on most individuals. Thus, interactions between both is mostly dependent on the quantity of consumed alcohol. When consumed in small amounts, alcohol does not usually negatively impact the effects of Cialis. Thus, when taken in moderation, it is possible to use both substances simultaneously in a safe and sexually satisfying way. However, it should be noted that doctors discourage users from mixing Cialis with alcohol.

Interaction with high doses of alcohol

Excessive alcohol consumption can have significantly adverse effects. Consumption of alcohol in large quantities is quite dangerous by itself. And like most medicines, Cialis must not be taken together with large amounts of alcohol. There are two main reasons for this.

The first one is that excessive consumption of alcohol will by itself decrease your level of libido. Alcohol in large quantities causes numbness and impairs sensitivity, thus reducing response to sexual stimuli. Another issue is dehydration: water loss in the body spurs the release of the hormone angiotensin (vasoconstrictor), which is associated with erectile dysfunction. Alcohol also directs blood to the liver so that it is metabolized by the body. Consequently, less blood is available for an erection, which can inhibit the drug from producing its desired effect.

The second reason is that Cialis, especially when combined with alcohol, can cause dizziness, nausea, vomiting, tachycardia and, most seriously of all, a sudden drop in blood pressure that may even lead to fainting. The blood pressure drop occurs because both ethanol and Cialis cause blood vessels to dilate. Vasodilation is a natural body process that can be catalyzed by drugs, but it can be dangerous when it happens very quickly, even without medications. The fact that both ethanol and Cialis are metabolized by the liver makes the interaction even more dangerous, since possible side effects become more likely (alcohol and Cialis have relatively similar side effects).

Small amounts of alcohol

Moderate alcohol consumption should not be reason for concern. But given that both substances can lower blood pressure, the safest approach is to limit alcohol intake to a minimum while using the ED drug in order to avoid such side effects as dizziness or heart palpitations.

DOES CIALIS LOWER BLOOD PRESSURE?

Cialis is a drug used to treat patients who suffer from erectile dysfunction. The drug works by increasing the flow of blood to the penis. It dilates the blood vessels to allow the flow of blood. Various studies have found that high blood pressure is often associated with erectile dysfunction. To this effect, most people are usually concerned about whether Cialis can lower blood pressure.

As a matter of fact, the use of Cialis lowers blood pressure. Moreover, this effect can be increased if the drug is taken together with a nitrate medication. The risk of lowering blood pressure, especially when an individual combines Cialis with other drugs, can have serious health consequences, such as fainting. People taking nitrates are strongly advised not to take Cialis, as it can significantly lower the blood pressure to unsafe levels.

Properly speaking, the drug was initially developed for the treatment of hypertension. However, patients taking other medications for treating blood pressure may take Cialis as an additional medication. People with uncontrolled blood pressure have been known to take tadalafil (the main active ingredient of Cialis) to treat their condition. As such, this shows that Cialis can indeed lower blood pressure.

Cialis can bring about a temporary decrease in blood pressure due to its mild systemic vasodilatory properties. Since doctors might prescribe tadalafil for people suffering from high blood pressure, they usually consider whether the vasodilatory effects of the medication can affect the patient adversely. This effect can be significant in some patients, and that is why physicians have to consider its effects before writing a prescription.

All in all, it is clear that Cialis can lower blood pressure. However, this property comes as a side effect of Cialis – although it is quite a common one – and varies from one individual to another. Some users may experience just a negligible decrease in blood pressure or no decrease at all.

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